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Why does ketogenesis occur?

Updated: 12/8/2022
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12y ago

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Ketogenesis is a metabolic process to form ketone bodies in mitochondrial matrix of hepatocytes in emergency condition from accumulated Acetyl-CoAobtained from increased incomplete fatty acid oxidation due to cellular glucose deprivation.

CoA is a complex structure which is impermeable to mitochondrial membranes, Acetate linked to CoA as AcetylCoA is also impermeable.The steps of Ketogenesis occur to remove the CoA from the molecules of AcetylCoA and form a permeable ketone body Acetoacetate( Primary Ketone body).

Acetoacetate then spontaneously decarboxylated to stable Acetone and reduced to Beta Hydroxy Butyrate (Secondary ketone bodies).

Thus Ketogenesis occur to remove the accumulated impermeable Acetyl-CoA from mitochondrial matrix by forming permeable ketonebodies.Ketogenesis removes the acetate carbon out of matrix and maintain the CoA pool of matrix.

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12y ago
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Q: Why does ketogenesis occur?
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