Why does work best at 37 degrees?

Answer 1

Pepsin works best at 37 C because that is it's optimal temperature. The temperature at which it works best. Every enzyme has one which is based on the molecular geometry and binding of the protein. it is also the same degrees of the core body temperature.

Answer 2

Enzymes work best at 37 degrees Celcius because this is the typical temperature of the human body, so enzymes have evolved to function optimally at this temperature. Changing the temperature can alter the shape and structure of the enzyme, affecting its ability to catalyze reactions efficiently.