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The cell membrane is impermeable to most ions. An ion channel is needed for cations and anions to cross the membrane, thus they can't freely pass the plasma membrane. Axons of neurons lack specific permeability for anions - which might explain why your asking this question and why you think cells lack anionic permeability (which they don't).

Ion channels in the axon have pores with high concentrations of negatively charged amino acids on the cellular and extracellular sides of the channel. This causes a repulsion of anion's while attracting cations, however being simple diffusion it's important not to suggest that the cations are being sucked out like a vacuum, the concentration gradient plays a predominant when dictating which ions and how fast they will be diffusion into our out of the cell.

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Q: Why is cell membrane impermeable to organic anions?
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