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Those are the parts of the brain that get damaged. As a person gets older, they may develop plaques in the blood vessels supplying the brain. Strokes, aneurysms, or other ischemia could damage those areas more directly. They could have Alzheimer's and/or Parkinson's Disease. That would mean that they have amyloid plaques around their neurons or Lewey bodies inside them, and possibly that they are less able to use acetylcholine, serotonin, and/or dopamine.

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