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Q: Why nucleophilic substitution reaction occure at position no 2 in pyridine?
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What are nucleophilic reaction?

A reaction in which a negative ion (nucleophile) attacks on a partially positive carbon atom then reaction is known as nucleophilic reaction, it may be substitution reaction or addition reaction.


Comment Pyridine undergo nucleophilic and electrophilic substitution reaction?

Pyridine will add to carbon 3 in electrophilic reactions, such as Bromine addition. However in a nucleophilic reaction, such as seen in the Chichibabin reaction, carbon #2 and #4 are substituted such as if NH2 - attacked. Draw out the resonance forms and you will see this, or consult any Organic text under heterocyclic Chemistry.In a C3 attack, the electrophile will destabilize the C2 and C4 position, to a great extent since N lacks an octet in one of these resonance forms.In a nucleophilic addition, addition at C2 or C4 allows the negative charge to be shared by Nitrogen thus is preferred to the C3 attack. Hope that helps. Dr Jim Romano CEO Romano Scientific CEO Orgoman.com Class of 1991 NYU


Why halobenzenes are less reactive towards nucleophilic substitution reaction?

i think the question is wrong.benzene doesn't respond nucleophilic substitution respond electrophilic substitution it is electrophilic then due to resonance there is a partial double bond between carbon of benzene and halogens.so halobenzenes are chemically inert towards electrophilic substitution.


What is SNi reaction?

The question is probably intended to be about SN1 reaction. See the following from Wikipedia, accessed Feb. 25, 2013: "The SN1 reaction is a substitution reaction in organic chemistry. "SN" stands for nucleophilic substitution and the "1" represents the fact that the rate-determining step is unimolecular".


What is the equation for the reaction involved when the bromine is mixed with the ethyne?

The Nucleophilic substitution of Halo alkanes


What is the reaction between pcl5 and pyridine?

experimental of reaction between pyridine and PCl5


What is ammonolysis?

It can be defined as followed. special type of nucleophilic substitution.


What is nucleophilic substitution reaction?

A nucleophile attacks an electrophilic site and replaces a leaving group. e.g. OH- attacks R-Br to give R-OH.


What is the products obtained when pyridine reacts with sodamide?

2-amino pyridine derivates by the reaction of pyridine with sodium amide and this reaction called chichibabinrection


What will iodine do when it is put in trichloromethane?

A nucleophilic substitution reaction would take place, replacing various numbers of chlorine atoms with iodine atoms. Thus a mixture of compounds is produced.


Why benzene undergo electrophilic substitution reaction easily and nucleophilic substution reaction with difficulty easily and?

the electron in benzene are delocalised making d ring to be elctron rich,thereby undergoing electrophilic substitution.benzene cannot undergo nucleophillic substitution,it can only undergo if it is substituted with an electron withdrawing group


Why aryl halides gives nucleophilic substitution very slowly?

The lone pair of electron present on the halogen atom overlaps with the adjacent pi bond electrons of the benzene ring and get delocalised. As a result of this the carbon-halogen bond strength increases and halogen atom can't be displaced easily.