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When asking why blood is drawn 'below' an IV site, it is presumed that this means distal (or further from the heart) when compared to the IV. The reason for drawing blood distal to the site of IV insertion is simple. When venous blood returns to the heart, administration of medications, electrolytes, and fluids is often through the IV. Therefore, we want to obtain blood which has not yet been affected by the medication or fluids given to the patient through the IV. For example, if a patient's blood magnesium levels are low, and we are giving therapeutic magnesium to increase these levels, we would want to monitor the effect of our treatment. Therefore, we would want to see the effect of magnesium infusion at a site without interference by the magnesium being infused through the IV. Therefore, we measure distal to the site of the IV, so that our blood sample represents the body's general levels magnesium, without influence from the IV line.

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