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In most cases, NO. There are exceptions to the rule on Asian cars. Nissans really hate fuel injection cleaners. But on American cars, if you use a bottle of fuel injection cleaner, and your O2 sensor goes bad, its not because of the FI cleaner. Its because the sensor has gone bad, or something else is wrong with the car. If your O2 sensor is bad, I recomend doing a tune up, plugs, wires, PCV valve, air filter, oil change, and the O2 sensor.

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Q: Will the use of fuel injection cleaners ruin oxygen sensors?
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