Asked in Down Syndrome
Would a male with Down syndrome and a female without Down syndrome have a child with Down syndrome?
July 19, 2010 12:31PM
There Is A Possibility. The statistical risk depends on the type of chromosome translocation.
Either parent with a 21/21 translocation can only have children with Down syndrome.
One healthy and one parent with a 14/21 translocation has 50/50 odds of a child with Down syndrome. After the first pregnancy, this couple has an 8% to 10% risk of Down syndrome with every further child. Statistically.
Anyone with a genetically transmissible disease or condition should seek genetic counseling as part of their overall family planning.