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Down Syndrome

Would a male with Down syndrome and a female without Down syndrome have a child with Down syndrome?


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July 19, 2010 12:31PM

There Is A Possibility. The statistical risk depends on the type of chromosome translocation.

Either parent with a 21/21 translocation can only have children with Down syndrome.

One healthy and one parent with a 14/21 translocation has 50/50 odds of a child with Down syndrome. After the first pregnancy, this couple has an 8% to 10% risk of Down syndrome with every further child. Statistically.

Anyone with a genetically transmissible disease or condition should seek genetic counseling as part of their overall family planning.