Crohn's disease is a form of inflammatory bowel disease (IBD). It usually affects the intestines, but may occur anywhere from the mouth to the end of the rectum (anus).
See also: Ulcerative colitis
Alternative NamesInflammatory bowel disease - Crohn's disease; Regional enteritis; Ileitis; Granulomatous ileocolitis; IBD- Crohn's disease
Causes, incidence, and risk factorsWhile the exact cause of Crohn's disease is unknown, the condition is linked to a problem with the body's immune system response.
Normally, the immune system helps protect the body, but with Crohn's disease the immune system can't tell the difference between normal body tissue and foreign substances. The result is an overactive immune response that leads to chronic inflammation. This is called an autoimmune disorder.
People with Crohn's disease have ongoing (chronic) inflammation of the gastrointestinal tract. Crohn's disease may occur in any area of the digestive tract. There can be healthy patches of tissue between diseased areas. The ongoing inflammation causes the intestinal wall to become thick.
There are five different types of Crohn's disease:
A person's genes and environmental factors seem to play a role in the development of Crohn's disease. The body may be overreacting to normal bacteria in the intestines.
The disease may occur at any age, but it usually occurs in people between ages 15 - 35. Risk factors include:
Symptoms depend on what part of the gastrointestinal tract is affected. Symptoms range from mild to severe, and can come and go with periods of flare-ups.
The main symptoms of Crohn's disease are:
Other symptoms may include:
A physical examination may reveal an abdominal mass or tenderness, skin rash, swollen joints, or mouth ulcers. Tests to diagnose Crohn's disease include:
A stool culturemay be done to rule out other possible causes of the symptoms.
This disease may also alter the results of the following tests:
DIET AND NUTRITION
No specific diet has been shown to improve or worsen the bowel inflammation in Crohn's disease. However, eating a healthy amount of calories, vitamins, and protein is important to avoid malnutrition and weight loss. Specific food problems may vary from person to person.
Certain types of foods may worsen diarrhea and gas symptoms, especially during times of active disease. Suggestions for diet during periods when symptoms are present include:
People who have a blockage of the intestines may need to avoid raw fruits and vegetables. Those who have difficulty digesting milk sugar (lactose) may need to avoid milk products.
Ask your doctor about extra vitamins and minerals you may need:
MEDICATIONS
Antidiarrheal drugs can help when you have very bad diarrhea. Loperamide (Imodium) can be bought without a prescription. Always talk to your doctor or nurse before using these drugs.
Medicines that may be prescribed include:
SURGERY
If medicines do not work, a type of surgery called bowel resection may be needed to remove a damaged or diseased part of the intestine or to drain an abscess. A procedure called anastomosis is done to connect the remaining two ends of the bowel.
Most patients with Crohn's disease will need bowel surgery at some time. However, unlike ulcerative colitis, surgically removing the diseased portion of the intestine does not cure the condition.
Patients who have Crohn's disease that does not respond to medications may need surgery, especially when there are complications such as:
Some patients may need surgery to remove the entire large intestine (colon), with or without the rectum.
See also:
Support GroupsThe Crohn's and Colitis Foundation of America offers support groups throughout the United States. See http://www.ccfa.org/chapters/
Expectations (prognosis)There is no cure for Crohn's disease. The condition is marked by periods of improvement followed by flare-ups of symptoms.
It is very important to stay on medications long-term to try to keep the disease symptoms from returning. If you stop or change your medications for any reason, let your doctor know right away.
You have a higher risk for small bowel and colon cancer if you have Crohn's disease.
ComplicationsCall for an appointment with your health care provider if:
Lichtenstein GR, Hanauer SB, Sandborn WJ; Practice Parameters Committee ofAmerican Collegeof Gastroenterology. Management of Crohn's disease in adults. Am J Gastroenterol. 2009 Feb;104(2):465-83. Epub 2009 Jan 6.
Fry RD, Mahmoud N, Maron DJ, Ross HM, Rombeau J. Colon and rectum. In: Townsend CM, Beauchamp RD, Evers BM, Mattox KL, eds. Sabiston Textbook of Surgery. 18th ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 50.
Rutgeerts P, Vermeire S, Van Assche G. Biological therapies for inflammatory bowel diseases. Gastroenterology. 2009 Apr;136(4):1182-97. Epub 2009 Feb 26.
crohns disease crohns disease
There is only one type of Crohns disease. Crohns disease can manifest anywhere in the digestive tract but it is the same disease no matter where it appears.
is bipolar and crohns disease linked together
There is no know cause of Crohns disease at this time. Research is ongoing as to the causes of Crohns disease.
No. Drug abuse history has never been linked to Crohns disease. Children as young as 3 can develop Crohns disease. Crohns is not something you have done to yourself.
The Crohns Disease Activity Index is a questionnaire used in research to help measure how the disease is affecting the patient.
Crohns disease
No.
Because Crohns disease has not been fully researched as to the causes, it cannot be prevented. Once diagnosed, the disease can be managed but never cured.
Crohns disease can do that.
Crohns symptoms can occur from mouth to anus. It is likely the original esophageal spasms were symptoms of Crohns disease that were undiagnosed until later.
yes