Neuroblastoma is a malignant (cancerous) tumor that develops from nerve tissue. It occurs in infants and children.
Causes, incidence, and risk factorsNeuroblastoma can occur in many areas of the body. It develops from the tissues that form the sympathetic nervous system (the part of the nervous system that controls body functions, such as heart rate and blood pressure, digestion, and levels of certain hormones).
Most neuroblastomas begin in the abdomen in the adrenal gland or next to the spinal cord, or in the chest. They may also start in other areas. Neuroblastomas can spread to the bones (face, skull, pelvis, shoulders, arms, and legs), bone marrow, liver, lymph nodes, skin, and around the eyes (orbits).
The cause of the tumor is unknown. Neuroblastoma is most commonly diagnosed in children before age 5. The disorder occurs in approximately 1 out of 100,000 children and is slightly more common in boys.
In most patients, the neuroblastoma has already spread when it is first diagnosed.
SymptomsThe first symptoms are usually fever, a general sick feeling (malaise), and pain. There may also be loss of appetite, weight loss, and diarrhea.
Other symptoms depend on the site of the tumor, and may include:
Brain and nervous system problems may include:
Signs vary depending on the location of the tumor. Examination of the abdomen with the hands (palpation) may reveal a mass. The liver may be enlarged, if the tumor has spread to the liver. Adrenal gland tumors can cause high blood pressure and a fast heart rate. Lymph nodes may be swollen.
X-ray or imaging tests are done to locate the main (primary) tumor and to see where it has spread. These include:
Other tests include:
Treatment varies depending on the location of the tumor, how much and where the tumor has spread, and the age of the patient. In certain cases, surgery alone is enough, but often other therapies are needed. Anticancer medications (chemotherapy) may be recommended if the tumor is widespread. Radiation therapy may also be used.
Support GroupsThe stress of illness can often be helped by joining a support group where members share common experiences and problems. See cancer - support group.
Expectations (prognosis)The expected outcome varies. In very young children with neuroblastoma, the tumor may go away on its own, without any treatment, or the tissues of the tumor may mature and develop into a benign (non-cancerous) tumor called a ganglioneuroma, which can be surgically removed. In other cases, the tumor spreads rapidly.
Response to treatment also varies. Treatment is often successful if the cancer has not spread, but if it has been spread, neuroblastoma is much harder to cure. Younger children often do better than older children.
Tumors with certain genetic characteristics may be harder to cure.
Children treated for neuroblastoma may be at risk for getting a second, different cancer in the future.
ComplicationsCall your health care provider if your child has symptoms of neuroblastoma. Early diagnosis and treatment improves the chance of a good outcome.
ReferencesDome JS, Rodriguez-Galindo C, Spunt SL, Santana VM. Pediatric Solid Tumors. In: Abeloff MD, Armitage JO, Niederhuber JE, Kastan MB, McKenna WG, eds. Clinical Oncology. 4th ed. Philadelphia, Pa; Churchill Livingstone Elsevier; 2008: chap 99.
Neuroblastoma is a malignant (cancerous) tumor that develops from nerve tissue. It usually occurs in infants and children.
Causes, incidence, and risk factorsNeuroblastoma can occur in many areas of the body. It develops from the tissues that form the sympathetic nervous system (the part of the nervous system that controls body functions, such as heart rate and blood pressure, digestion, and levels of certain hormones).
Most neuroblastomas begin in the abdomen in the adrenal gland or next to the spinal cord, or in the chest. Neuroblastomas can spread to the bones (face, skull, pelvis, shoulders, arms, and legs), bone marrow, liver, lymph nodes, skin, and around the eyes (orbits).
The cause of the tumor is unknown. Neuroblastoma is most commonly diagnosed in children before age 5. The disorder occurs in approximately 1 out of 100,000 children and is slightly more common in boys.
In most patients, the neuroblastoma has already spread when it is first diagnosed.
SymptomsThe first symptoms are usually fever, a general sick feeling (malaise), and pain. There may also be loss of appetite, weight loss, and diarrhea.
Other symptoms depend on the site of the tumor, and may include:
Brain and nervous system problems may include:
Signs vary depending on the location of the tumor.
X-ray or imaging tests are done to locate the main (primary) tumor and to see where it has spread. These include:
Other tests include:
Treatment varies depending on:
In certain cases, surgery alone is enough. Often, though, other therapies are needed. Anticancer medications (chemotherapy) may be recommended if the tumor has spread. Radiation therapy may also be used.
High-dose chemotherapy, followed by autologous stem cell transplantation, is being studied for use in children with very high-risk tumors.
Support GroupsThe stress of illness can often be helped by joining a support group where members share common experiences and problems. See cancer - support group.
Expectations (prognosis)The outcome varies. In very young children with neuroblastoma, the tumor may go away on its own, without any treatment. Or, the tissues of the tumor may mature and develop into a non-cancerous (benign) tumor called a ganglioneuroma, which can be surgically removed. In other cases, the tumor spreads quickly.
Response to treatment also varies. Treatment is often successful if the cancer has not spread. If it has spread, neuroblastoma is much harder to cure. Younger children often do better than older children.
Tumors with certain genetic characteristics may be harder to cure.
Children treated for neuroblastoma may be at risk for getting a second, different cancer in the future.
ComplicationsCall your health care provider if your child has symptoms of neuroblastoma. Early diagnosis and treatment improves the chance of a good outcome.
ReferencesDome JS, Rodriguez-Galindo C, Spunt SL, Santana VM. Pediatric Solid Tumors. In: Abeloff MD, Armitage JO, Niederhuber JE, Kastan MB, McKenna WG, eds. Clinical Oncology. 4th ed. Philadelphia, Pa; Churchill Livingstone Elsevier; 2008:chap 99.
Reviewed ByReview Date: 02/07/2012
Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
Neuroblastoma-- Neuroblastoma is a tumor of the adrenal glands or sympathetic nervous system. Neuroblastomas can range from being relatively harmless to highly malignant.
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After completion of a course of treatment for neuroblastoma, physicians sometimes recommend that the child undergo an investigative operation. This procedure allows the treatment team to evaluate how effective treatment.
No alternative therapy has yet been reported to substitute for conventional neuroblastoma treatment. Complementary therapies--such as retinoic acid therapy--have been shown to be beneficial to patients when administered after a conventional.
Neuroblastoma may be a genetic disease passed down from the parents. In 2004, a group of German researchers reported that a series of neuroblastomas demonstrated a consistent pattern of deletions and overrepresentations on chromosomes 3, 10.