This is not easy at all due to very poor engineering design by Ford! This can be done but will take several hours, expect to spend a weekend day to change all eight plugs, be patient and take breaks...Be sure to use 'Autolite double platinum electrode' or better plugs as you will not want to do this often! It is worth the money here to put in the best plugs available! After removing all of the stuff that's in the way which is practically everything on top of the engine, use electrical tape to tape the spark plug to a 5/8in deep socket, not a spark plug type of socket ( you will never get a 5/8in spark plug socket out of that deep rusty hole without removing the plug again because the foam inside the sparkplug socket in combination with the rust in the hole will grip the socket more than the extension does to the socket resulting in a stuck socket), use one long extension. Upon reinstallation, use electrical tape to tape the coil mount screw to a socket. Be careful not to drop any screws, you will not have fun trying to find them, there are no spares and they are all needed! The coil connector plastic lock clip breaks off very easily too! Do not try to install without the lock clip, the connector will fall off! Run a couple of black UV resistant plastic tie wraps together and then between the two input wires of each coil connector and attach against something solid such as the fuel rail mounting brackets. Take your time, be patient and Good luck, your truck will soon be good for another 100,000 miles!
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http://www.ford-trucks.com/article/idx/0/100/article/How_To_Change_Spark_Plugs_on_46__54_Liter_F150s.html
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disconect the coil and remove the 7mm bolt that holds down the coil, remove the coil then plug.
50,000 miles.