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The cell is aneuploid, and the condition is aneuploidy.

The human haploid number is 23. So a diploid cell (one with two sets of chromosomes, one set from each parent) has 46 chromosomes.

Occasionally a mistake occurs in cell division, and the cell does not detect the mistake and stop the division. The mistake involves attachment of spindle fibers to centromeres. The consequence is that, instead of two chromosomes separating and going to opposite poles at anaphase, both members of a pair travel to the same pole. One daughter cell therefore lacks a chromosome, and one has an extra copy.

Among the conditions caused by this non-disjunction are Down's syndrome and Klinefelter's syndrome.

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