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There are three special types of cells found only in bone. They are:

Osteoclasts , which are large cells the dissolve the bone. They originate in the bone marrow and are related to white blood cells and are found on the surface of the bone mineral next to dissolving bone.

Osteoblasts, which form new bone. Originating in the bone marrow, they have one nucleus. They work in teams to build bone from bone collagen and other protein. They also control calcium and mineral deposition, and are found on the surface of new bone. When they have finished filling in a cavity, they become flat and line the surface of the bone. They regulate passage of calcium into and out of bone. In addition, they respond to hormones by making special proteins that activate the osteoclasts.

Osteocytes, which are cells inside the bone. Osteoclasts and osteoblasts may turn into osteocytes white new bone is being formed, and then osteocytes get surrounded by new bone. Osteocytes send out long branches that connect to other osteocytes. They can sense pressures or cracks in bone and help direct where osteoclasts dissolve bone.

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