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The difference between Oxygen - 15 and Oxygen - 16 is that of Isotope.

Oxygen's atomic number is 8 as it contains 8 proton but the neutron number may vary in order to form an isotope, the oxygen found in the air is 98 percent oxygen 16, the rest is oxygen 15.

Oxygen 16 = 8 protons, 8 neutrons, 8 electrons.

16 is the mass number which is equal to the (number of proton + number of neutrons)

Oxygen 15 = 8 protons, 7 neutrons, 8 electrons.

15 is the mass number which is equal to the (number of proton + number of neutrons)

Oxygen 15 is known as the "Isotope" of Oxygen 16.

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