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You can design an 8-to-1 multiplexer using two 4-to-1 multiplexers, and a 2-1 multiplexor.

The 8 inputs would be connected to the two 4-1's using two of the selector inputs and the outputs of the two 4-1's would be connected to the 2-1 using the third selector input.

If the 4-1's have tri-state ouputs, you can eliminate the 2-1, and use the third selector input, and its complement, to drive the two 4-1's. You will need an inverter in this case. You just need to be careful that the 4-1's do not drive the output at the same time - this could result in large current spikes on GND and VCC, and you don't want that - open collector outputs, as opposed to totem pole outputs, are a wonderful solution to this problem - it all depends on required propagation delay time.

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