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No, it should not (especially if you are referring to the condom and not the oral contraceptive pill). This may be related to the CYP3A4 enzyme that is responsible for slowly breaking down many drugs and toxins in our body, with the OCP (oral contraceptive pill) being one of the affected drugs. This ensures that the drug levels (and of course toxin levels) do not stay in our bodies permanently. However grapefruit juice is an inhibitor of the enzyme, and as such it slows down the breakdown of the contraceptive in the body. By applying the double negative makes a positive rule, you'll understand that this would cause the effect of the drug to be "stronger" instead. However this does not mean that women should take less OCPs and more grapefruit juice if they want to prevent pregnancy, this "stronger" effect only happens in some drugs, but has yet to be proven in OCPs. St. John's Wort, which is available over the counter on the other hand is a CYP3A4 inducer, and that has the opposite effect in causing the OCP to be broken down faster, so it has been proven in some clinical trials that women on both should approach their doctor for advise on tailoring their OCP dosage, else be at higher risk of unexpected pregnancy

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16y ago
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14y ago

There is warning about this on Drugs.com that specifically states "Do not eat grapefruit or drink grapefruit juice while you use Ortho Evra Patch."

Go here to read entire list.

http://www.drugs.com/cdi/ortho-evra-patch.html

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11y ago

Dr. Derendorf adds another point: For birth control pills, grapefruit may increase the levels of some birth control components, but not decreasethe effectiveness that would result in pregnancy.

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9y ago

No,not at all. The only thing that can affect Birth Control is certain medications

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13y ago

Not necessarily. Just use moderation as with anything else.

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10y ago

Grapefruit juice does not affect how well Depo Provera works. Very few medications affect depo Provera.

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Q: Can grapefruit juice affect the birth control pill?
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Prune juice does not affect how well the birth control pill works. There's no increased risk of pregnancy.


What medications interfere with grapefruit juice?

grapefruit can interact with birth control and certain antibiotics. so if you are sexually active and into grapefruits try a different contraceptive for a week after your last grapefruit


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No. It does not. Nor will it ever. That is a complete myth. The only ones you need to worry about, are ones like Fresca which contain REAL grapefruit juice. Grapefruit is known to interact with many drugs, including birth control. Grapefruit slows down your body's ability to eliminate the estrogen from your pills which leaves it circulating in your system longer which then greatly increases all of the risks that birth control carries. You can still drink it, (I do) but sparingly and not often.


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