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The most important feature that makes functional to a protein or an enzyme is its three dimensional structure based on its tertiary structure. Either, a structural protein, where alpha helices and beta sheets are vital to its function, or an enzyme, where the shape of its active site is crucial for its biological activity, the tertiary structure is the most important characteristic. In fact, the process called "protein folding" is one of the key biochemical areas of study for the scientific community.

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