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Urea was first discovered in urine in 1727 by the Dutch scientist Herman Boerhaave, though this discovery is often attributed to the French chemist Hilaire Rouelle.[3] In 1828, the German chemist Friedrich Wöhler obtained urea by treating silver isocyanate with ammonium chloride.[4][5]AgNCO + NH4Cl → (NH2)2CO + AgCl

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