The factors affecting nerve conduction velocity are as follows:
(i) Axon diameter:
An axon with a larger diameter conducts faster. In an unmyelinated fiber, the speed of propagation is directly proportional to the square root of the fiber diameter (D), i.e.,
Conduction velocity a D
(ii) Myelination and saltatory conduction:
Myelination speeds up conduction. Thus, the action potential travels electrotonically along the long myelinated segments, and fresh action potentials are generated only at the nodes. This is called saltatory conduction. In a myelinated neuron, the conduction velocity is directly proportional to the fiber diameter (D).
(iii) Temperature:
A decrease in temperature slows down conduction velocity, (iv) Resting membrane potential. Effect of RMP changes on conduction velocity is quite variable. Usually, any change in the RMP in either direction (hyper polarization or depolarization) slows down the conduction velocity.
A nerve conduction velocity test is a medical procedure used to assess how quickly electrical impulses travel through nerves. It helps diagnose conditions that affect the nervous system, such as nerve damage, neuropathy, and carpal tunnel syndrome, by measuring the speed of nerve signals. The test involves placing electrodes on the skin to stimulate the nerve and recording the response to determine the speed of conduction.
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It measures the ability of the nerve to conduct electrical signals
The sensitivity of the receptors, velocity of nerve conduction, and the number of neurons and synapses involved to name a few.
velocity proportional to square root of diameter
The diameter of the nerve fiber and the presence or absence of a myelin sheath are the two main factors that affect the speed of nerve signals. Larger diameter fibers and a myelin sheath help to increase the speed of nerve signal conduction.
For unmyelinated nerves there is a relationship between axon diameter and conduction velocity. Larger diameter nerves conduct faster. For myelinated nerves the a larger diameter nerve will conduct faster between the nodes of ranvier where the action potential is propagated. Conduction is said to be saltatoryas it jumps from node to node.
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Nerve conduction velocity studies are diagnostic tests that measure the speed at which electrical impulses travel along nerves. They help to evaluate nerve damage, identify specific nerve disorders, and determine the extent and location of nerve injury. These tests are commonly used to diagnose conditions like carpal tunnel syndrome, peripheral neuropathy, and nerve injuries.
Heavily myelinated, large diameter fibers
Myelination will speed the nerve conduction velocity considerably. Myelin is found in Schwann cells which encircle a given axon. It acts mainly as an insulator so that depolarization in one cell does not set off depolarizations in adjoining cells. When a neural membrane is depolarized, local currents are set up between positive and negative ions causing membrane conduction. In myelinated fibers, the local currents go from one internode (or node of Ranvier) in between two Schwann cells to the next internode. Thus we have "salutatory conduction" where a neural impulse actually jumps from one internode to the next without being conducted down the entire cell membrane.
Nerve Conduction Velocity scans costs Rs1500/-What_is_the_cost_of_a_Nerve_Conduction_Test