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You're doubling up on the genes, so whatever is behind those dogs, genetically speaking, is going to be amplified. By inbreeding, you are going to bring out the recessive genes that your dogs carry. So if, say, they both carry copies of a blindness gene, then it is likely the puppies will be blind. Or if mom's dad was a biter, by doubling up on that dog's genes, you are more likely to see it expressed in the litter. (ie, you'd be more likely to get biters.) Inbreeding is a very powerful tool. But it is best left to experienced breeders. One drawback to breeding such a litter is that you usually have to cull (euthanize or spay/neuter) a lot of puppies when undesireable genes pop up.

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