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I assume you are referring to methods of measuring small value resistances, as in locating short circuits on a PC card.

Two probe is the method used by standard ohm meters. This works OK for most resistance values, as the resistance of the leads & probes is much lower than the resistance being measured. But when the resistance being measured gets very tiny (e.g. a few milliohms) it fails as the resistance of the leads & probe are of the same order of magnitude and are in series with it.

Four probe solves this problem by using two probes connected to a current source to drive the resistance and a separate two probes connected to a precision voltmeter calibrated in milliohms. The voltage drop in the leads due to the test current does not get measured by the calibrated voltmeter, as it does in two probe method. There is no voltage drop in the measurement leads as the voltmeter is high impedance.

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