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Alcohol is permeable to many areas of the brain.

However, the main areas affected are:

1) the neocortex - alcohol inhibits activity in the neocortex, responsible for higher-level thinking and execution;

2) the hippocampus - by inhibiting NMDA receptors and increasing GABA-A receptor activity in this region, memory impairment results. In high enough doses, even blackouts can occur, whereby short-term to long-term memory consolidation has been effectively blocked altogether;

3) the cerebellum - inhibiting this region, primarily via GABA-A receptor modulation, reduces fine movement abilities, posture, coordination, etc..;

4) osmoreceptors in the hypothalamus - this results in poor modulation of ADH (antidiuretic hormone), resulting in increased urination and poor water retention, leading to dehydration;

5) in high enough doses, even the lowest regions of the brain can be affected, leading to unconsciousness, coma, or death

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