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If the compounds are liquids, here is what determines water solubility: Water molucules have polarity. The solubility of a liquid is determined by its polarity. Polar substances often contain OH-, SH- and NH2- groups. The more of these groups a liquid contains, the more water-soluble it is. These groups can form hydrogen bonds with water, which are very strong. Because these bonds are very strong a molecule that contains more OH-, SH- and NH2- groups is more water-soluble. If the compound is a gas, Henry's Law determines the solubility of gasses in water. This law links the partial pressure of a gas to its mole-fraction in the liquid phase, and thus declares how much of the gas is dissolved. According to calculations from Henry's Law oxygen is more water-soluble than nitrogen.

Henry's Law describes as follows:

P = H * x

In which p is the partial pressure of a gas, H is a constant that differs for each gas and x is the mole-fraction of the gas in the liquid phase.

Some gasses have a specific way of acting when they are dissolved.

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