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Grapefruit Juice

Grapefruit juice is a beverage made of fresh grapefruit. It is high in vitamin C and has tart to very sour flavor.

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How many grapefruits in one cup of grapefruit juice?

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Six glasses

  1. Before breakfast and after breakfast
  2. before lunch and after lunch
  3. and before dinner and after dinner.

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Please note however that a US study showed that drinking just a small glass of grapefruit juice every day, increases your risk of dgetting kidney stones by 44%.

Can you drink grapefruit juice while taking lamictal?

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Yes you can eat anything with it it doesn't inhibit your jaw muscles but seriously it may potentiate it's effects a bit

Does grapefruit juice affect blood pressure?

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It can. Grapefruits and grapefruit juice has been known to alter the metabolism of some medications. Hence: if you are taking blood pressure medicine and ingest grapefruit, the medication may cause some side effects, which can include alerting blood pressure. It is actually like an "enhancer". It can make it seem like you took 5x or more the dose that you originally took. Unfortunately, this can lead to dangerous side affects. Not all people will be affected, as it ineracts with a specific enzyme in your intestines. Talk to your doctor before ingesting grapefruit when on medications.

How we are able to drink juice using straw?

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put your mouth on the straw and suck it with your mouth

Why do you crave grapefruit juice?

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Many nutritionists believe that your body knows it needs certain nutrients and will crave the foods that provides those nutrients. Could be vitamin c for example is something your body knows it needs, so you will crave a juice which contains that vitamin.

Does Mountain Dew have any grapefruit juice or grapefruit related ingredients in it that could cause a problem for people taking cholesteral medication?

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No, Mountain Dew contains orange juice and citrus "flavors"; these would not affect your medications.

Should you avoid drinking grapefruit juice while taking azithromycin?

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Grapefruit has a lot of Vitamin C plus some enzymes that seem to speed up things . (For a while back in the 60's- grapefruit was thought to be a fat burner. )

Some antibiotics i.e. Erythromycin and other drugs which are in this class (the Not Pencillins) do not mix well at all, especially with Garpefruit. So those of you who take Erythromycin because of your pencillin allergies should be careful; especially when taking megadoses of Vitamin C or eating grapefruit.

The end result is your liver gets a big buildup of drugs it cannot handle - you are actually poisoning your self because the drugs are not working properly.

Here is the science: Erythromycin competes - It does the exact same thing as Vitamin C: it inhibits the cytochrome P450 system, particularly the CYP3A4 isozyme, which can cause it to affect the metabolism of many different drugs, not just Vitamin C.

I am not the pharmacist- just a smart nutritionist student who knows biochemistry. When I graduate I will sign this. In the meantime you are provided with the following

quoted directly from a professional source D.McAuley,

with references GlobalRPH.com

His site is a great study guide as well. Just always give him credit because he has copyrighted the site.

" Grapefruit juice is a potent inhibitor of the intestinal cytochrome P-450 3A4 system (specifically: CYP3A4 - mediated drug metabolism) which is responsible for the first-pass metabolism of many medications. This interaction can lead to increases in bioavailability and corresponding increases in serum drug levels.

In many cases, the increased serum drug levels can produce some readily observable symptoms. Here are a few examples of adverse effects that are possible when the following medications are taken concurrently with grapefruit.

(1) Excessive sedation: benzodiazepines.

(2) Increased risk of rhabdomyolyis: HMG-CoA reductase inhibitors (statins)-- there are some exceptions.

(3) Symptomatic hypotension: dihydropyridine calcium antagonists (some exceptions exist). (4) QT interval prolongation: astemizole, cisapride, pimozide, terfenadine. "Drug interactions may be most apparent when patients are stabilized on the affected drug and the CYP3A4 inhibitor is then added to the regimen." 5

CONVERSELY THE VITAMIN C THAT IS FACILITATED BY THE ENZYMES IN GRAPEFRUIT IS NOT ALL BAD>>>> the problem is that the drugs you take work on the same enzyme activation sites or pathways and only one thing can work well at a time or in the case of some drugs like the heart medicines the heartbeat is sped up or slowed down which is NOT what the doctor ordered when he put you on the medication.

There may be some pharmacological advantages to this interaction. If the interaction is taken into account during the initialization of drug therapy it is possible to decrease drug dosages. This concept can be applied to cyclosporine therapy. If a patient regularly consumes grapefruit, lower dosages of cyclosporine will be required, which will lead to lower drug costs.

IN CONCLUSION

Grapefruit juice is not the only inhibitor of this enzyme system. Other drugs which have a similar effect include: clarithromycin (Biaxin ®), erythromycin (E-Mycin ®, others), itraconazole (Sporonox ®), ketoconazole (Nizoril ®), nefazodone (Serzone ®), and ritonavir (Norvir ®). "

References:

1.

Bailey DG, Dresser GK. Grapefruit juice-lovastatin interaction. Clin Pharmacol Ther. 2000 Jun;67(6):6902.

Bistrup C, Nielsen FT, Jeppesen UE, Dieperink H. Effect of grapefruit juice on Sandimmun Neoral absorption among stable renal allograft recipients. Nephrol Dial Transplant. 2001 Feb;16(2):373-7.3.

Bramer SL, Brisson J, Corey AE. Effect of multiple cilostazol doses on single dose lovastatin pharmacokinetics in healthy volunteers. Clin Pharmacokinet. 1999;37 Suppl 2:69-77.4.Damkier P, Hansen LL, Brosen K. Effect of diclofenac, disulfiram, itraconazole, grapefruit juice and erythromycin on the pharmacokinetics of quinidine. Br J Clin Pharmacol. 1999 Dec;48(6):829-38.5.

Dresser GK, Spence JD, Bailey DG. Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition. Clin Pharmacokinet. 2000 Jan;38(1):41-57.6.

Dresser GK, Bailey DG, Carruthers SG. Grapefruit juice--felodipine interaction in the elderly. Clin Pharmacol Ther. 2000 Jul;68(1):28-34.7.Eagling VA, Profit L, Back DJ. Inhibition of the CYP3A4-mediated metabolism and P-glycoprotein-mediated transport of the HIV-1 protease inhibitor saquinavir by grapefruit juice components. Br J Clin Pharmacol. 1999 Oct;48(4):543-52.8.

Evans AM. Influence of dietary components on the gastrointestinal metabolism and transport of drugs Ther Drug Monit. 2000 Feb;22(1):131-6.9.

Fukuda K, Guo L, Ohashi N, Yoshikawa M, Yamazoe Y. Amounts and variation in grapefruit juice of the main components causing grapefruit-drug interaction. J Chromatogr B Biomed Sci Appl. 2000 May 12;741(2):195-203.10.

Fuhr U. [Clinically significant" new drug interactions]. Med Klin. 2000 May;95(1 Spec No):18-22.11.

Fuhr U, Maier-Bruggemann A, Blume H, Muck W, Unger S, Kuhlmann J, Huschka C, Zaigler M, Rietbrock S, Staib AH. Grapefruit juice increases oral nimodipine bioavailability. Int J Clin Pharmacol Ther. 1998 Mar;36(3):126-32.12.

Garg SK, Kumar N, Bhargava VK, Prabhakar SK. Effect of grapefruit juice on carbamazepine bioavailability in patients with epilepsy. Clin Pharmacol Ther. 1998 Sep;64(3):286-8.13.Kanazawa S, Ohkubo T, Sugawara K. The effects of grapefruit juice on the pharmacokinetics of erythromycin. Eur J Clin Pharmacol. 2001 Jan-Feb;56(11):799-803.14.

Kane GC, Lipsky JJ. Drug-grapefruit juice interactions. Mayo Clin Proc. 2000 Sep;75(9):933-42.15.

Lee AJ, Chan WK, Harralson AF, Buffum J, Bui BC. The effects of grapefruit juice on sertraline metabolism: an in vitro and in vivo study. Clin Ther. 1999 Nov;21(11):1890-9.16.Lilja JJ, Kivisto KT, Neuvonen PJ. Grapefruit juice increases serum concentrations of atorvastatin and has no effect on pravastatin. Clin Pharmacol Ther. 1999 Aug;66(2):118-27.17.Lilja JJ, Kivisto KT, Backman JT, Lamberg TS, Neuvonen PJ. Grapefruit juice substantially increases plasma concentrations of buspirone. Clin Pharmacol Ther. 1998 Dec;64(6):655-60.18.

Lilja JJ, Kivisto KT, Neuvonen PJ. Duration of effect of grapefruit juice on the pharmacokinetics of the CYP3A4 substrate simvastatin. Clin Pharmacol Ther. 2000 Oct;68(4):384-90.19.

Lilja JJ, Kivisto KT, Backman JT, Neuvonen PJ. Effect of grapefruit juice dose on grapefruit juice-triazolam interaction: repeated consumption prolongs triazolam half-life. Eur J Clin Pharmacol. 2000 Aug;56(5):411-5.20.

Libersa CC, Brique SA, Motte KB, Caron JF, Guedon-Moreau LM, Humbert L, Vincent A, Devos P, Lhermitte MA. Dramatic inhibition of amiodarone metabolism induced by grapefruit juice. Br J Clin Pharmacol. 2000 Apr;49(4):373-8.21.

Mitsunaga Y, Takanaga H, Matsuo H, Naito M, Tsuruo T, Ohtani H, Sawada Y. Effect of bioflavonoids on vincristine transport across blood-brain barrier. Eur J Pharmacol. 2000 May 3;395(3):193-201.22.

Ozdemir M, Aktan Y, Boydag BS, Cingi MI, Musmul A. Interaction between grapefruit juice and diazepam in humans. Eur J Drug Metab Pharmacokinet. 1998 Jan-Mar;23(1):55-9.23.

Singh BN. Effects of food on clinical pharmacokinetics. Clin Pharmacokinet. 1999 Sep;37(3):213-55. Review.24.

Zhang H, Wong CW, Coville PF, Wanwimolruk S. Effect of the grapefruit flavonoid naringin on pharmacokinetics of quinine in rats. Drug Metabol Drug Interact. 2000;17(1-4):351-63.

© D.McAuley, GlobalRPH.com 2001

Can you drink grapefruit juice on a low carbohydrate diet?

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Fruit juice, fresh, unsweeted is good on any diet. Just the amounts allowed need to be tended to. A diabetic diet or low carb diet

22 grams of carbs for 1 cup of fresh grapefuit juice. Allow yourself 4 ounces....the usual serving of a juice glass. If you are eating it as the fresh fruit/grapefruit, the whole grapefruit is allowed. A 4.5 inch diameter grapefruit has approx 27 grams.

This is is 2 fruit servings. So cut it in half, keep it for the next day in plastic wrap.

Can I drink juice with suboxone?

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why cant you eat grapefruit while taking suboxone

Does grapefruit juice get THC out of your system?

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No, THC stay in the fats and the only thing that rids it from the body is time. For your metabolism to breaks down these fats storing the THC. Only thing you can do to "speed up" the proses is exercising and diet. Other you can do to pass incoming drug test is to mask the THC using some good detox or urine sub.

What drink has cranberry juice a splash of seven up grapefruit juice and vodka?

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Sea Breeze (Massachusetts style)Drink Type: CocktailIngredients4 oz. Cranberry Juice

1 1/2 oz. Vodka

1 oz. Grapefruit Juice

InstructionsFlash blend and pour over ice. Garnish with a lime slice.

Can you drink grapefruit juice while taking perindopril?

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The warning label for Cardura does not say anything about grapefruit or grapefruit juice. Therefore, it should be safe to drink grapefruit juice while taking this medication.

Can you drink grapefruit juice and take crestor?

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Yes you can take grapefruit with tricor. Tricor coming under fibreate family not the statin family. You should limit grapefruit juice and fresh grapefruit consumption while taking statins, as grapefruit can interfere with the liver's ability to metabolize these medications.

What is the name of the cocktail made with grapefruit juice and vodka?

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The drink is actually called a Greyhound. If salt is added to the rim, it is called a Salty Dog.

Vodka and Orange juice is called a Screwdriver and Vodka and Prune juice is called a Pile Driver!

What color would a universal indicator turn with grapefruit juice?

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pink and red in acid and dark green

How do you freeze fresh grapefruit juice?

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We have a grapefruit tree in our yard and had over 200 grapefruit this year. While we gave many away, we didn't want to throw them out or waste so I juiced them and froze the juice. I used leftover plastic containers however some of the ones I used turned out to be a poor choice. When I ran out of V8 and old Tropicana OJ containers, I began using liter coke bottles and water bottles. The water bottles seem to have reacted with the grapefruit juice in the freezer because the juice tasted awful--it had a chemical taste. I am going to thaw the liter cola bottles and see how they fared. I got about 10 liters of grapefruit so it appears much of my work may have been in vain. I haven't found any good information on this topic but will keep looking. This is just my own experience.

Is freshly squeezed grapefruit juice a solution and why?

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No because it has to be stirred to look like one substance. It is a suspension.

Is lemon juice or grapefruit juice more acidic?

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I think they are both citric acid but lemon juice is more concentrated.

Where in Atlanta can you buy Minute Maid frozen grapefruit juice?

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I love the Minute Maid Frozen Lemon Juice, use all the time. Having trouble finding this product Help.

Does grapefruit juice affect ED medicine?

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I am pretty sure you are not suppose to take them together

Can you take pristiq and grapefruit juice?

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I don't think there's any harm in that