midril

If trazodone does impact dopamine, it does so very slightly, and such effect is negligible. So, I would say no.

Trazodone is an agonist for the 5-HT (serotonin)-1A receptor (similar to buspirone, where it acts to reduce anxiety).

It also antagonizes (blocks) the following receptor subtypes:

- 5-HT 2A, 2B, and 2C

- alpha-1 and alpha-2 adrenergic receptors

- histamine-1 receptor

LSD mainly affects the Cerebral Cortex. LSD is a serotonin receptor agonist and much of its hallucinogenic effects are thought to result from binding to the 5-HT2A serotonin receptor in particular. LSD also affects all subtypes of dopamine receptor and all subtypes of adrenoreceptor.

The serotonin receptor down-regulation has an antidepressant effect if it results in a decrease in post-synaptic neuron activation by activation of the 5-HT receptors within the rostral ventrolateral medulla.

The 5-ht receptors.