In the play "Oedipus Rex" by Sophocles, Oedipus believes that Creon is framing him for the murder of King Laius in order to undermine his rule and gain power. Oedipus is blinded by his own pride and determination to uncover the truth, leading him to accuse Creon without concrete evidence. As the play progresses, Oedipus realizes his tragic mistake and the devastating implications of his actions.