She married both of her brothers:

- Ptolemy XIII Theos Philopator

- Ptolemy XIV

Caleopetra married with her brother Ptolemy XIII Theos Philopator and with Ptolemy XIV.

Cleopatra VIII Philopator had three husbands. Her husbands were Ptolemy XIII Theos Philopator, Ptolemy XIV, and perhaps most famously, Mark Antony.

Cleopatra was married to her Father (Ptolemy XII )brothers, Ptolemy XIII and Ptolemy XIV, which was the Egyptian custom. Also Married to Julius Cesar.

Cleopatra VII became the sole ruler of Egypt with the help of Caesar, who eleminated her two siblings and co-regents, Ptolemy XIII Theos Philopator and Arsinoe IV.