Scientists have found that toxic fugu have unique exocrine
glands for the secretion of tetrodotoxin. The fish appear to
actively produce the toxin, rather than passively acquire it from
the environment.
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neurotoxins, like tetrodotoxin
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Tetrodotoxin blocks action potentials by binding with the
voltage-gated, fast sodium (Na+) channels in neural membranes.
This prevents the influx of sodium ions required to propagate an
action potential.