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Can a retrovirus change DNA in human sperm cells?

Updated: 8/17/2019
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12y ago

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The only way a retrovirus can change the DNA in a sperm cell is if it successfully implants its own DNA into the sperm DNA.

Studies have been done with the HIV retrovirus to show that the virus can successfully get inside a sperm cell - but it has never been shown that the HIV virus successfully implants its DNA into the sperm DNA.

In order to get to sperm in the first place, a retrovirus has to get past the blood-testes barrier - which protects developing sperm from outside infections.

The only way HIV is able to do this is because it infects white blood cells which are able to sneak past those defenses.

So, any retrovirus that has a chance of infecting a sperm cell must first be able to get past the blood-testes barrier - which seems to be limited to only retroviruses who are able to bind to white blood cells. Cells have unique binding cites, and only certain viruses are able to attach to certain ones.

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Q: Can a retrovirus change DNA in human sperm cells?
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