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Yes, these medicines can be taken together safely, as long as it is done appropriately. Obviously, both of these medicines can be sedating, and there should be some caution whenever two medicines that are sedating are used together. It is not good to be started on both medicines at the same time. But if already taking one medicine, so that it is known how the first medicine is affecting you, there can be an appropriate assessment of whether the first medicine is causing such sedation that the second medicine can be used safely.
For example, if already taking Norco to help ease pain and the patient is now having difficulty sleeping despite being on the Norco, so the Norco is not causing sufficient sedation to help sleep, then the Ambien can be added.
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