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Bit of a grey area this, due to SJW falling into a different category of anti-depressant than those which are strictly forbidden. After some time of researching for my own benefit, i found the last line (i've highlighted bold) of this paragraph from an article on http://www.angelfire.com/mn2/illstandbyyou/stjohn.html to be the most offputting to want to risk it tho. -

"St. John's wort may cause serious toxicity when taken with other antidepressants, including MAO-inhibitors, SSRI's, and tricyclic antidepressants. Possible reactions include very high blood pressure or "serotonin syndrome," (characterized by shivering, muscle jerking, restlessness, anxiety, and wide swings in blood pressure or heart rate). St. John's wort also may have potential to cause these symptoms when used along with the dietary supplement 5-HTP (5-hydroxytryptophan), the common over-the-counter cough suppressant dextromethorphan, or opiate analgesics such as codeine, meperidine, tramadol, or hydrocodone."

That said, reading the whole page gave me the impression that the author possibly wasn't a great fan of herbal remedies, with their non-stringently-tested-nor-endorsed-by-scientists ways!

Bit of a rubbish conclusion then. Sorry. - Ask your gp before mixing them is my best advice.

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12y ago
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12y ago

St. John's wort may cause serious toxicity when taken with other antidepressants, including MAO-inhibitors, SSRI's, and tricyclic antidepressants. Possible reactions include very high blood pressure or "serotonin syndrome," (characterized by shivering, muscle jerking, restlessness, anxiety, and wide swings in blood pressure or heart rate). St. John's wort also may have potential to cause these symptoms when used along with the dietary supplement 5-HTP (5-hydroxytryptophan), the common over-the-counter cough suppressant dextromethorphan, or opiate analgesics such as codeine, meperidine, tramadol, or hydrocodone.

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10y ago

Yes, and the SJW will prolonge the "high" because it slows down the metabolism of the hydrocodone.

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12y ago

No

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Q: Can you take hydrocodone and st johns wort in the same day?
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