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At the beginning of 'The Sign of Four,' Watson asks, 'Which is it today morphine or cocaine?' though we are not told of any morphine use until 'The Adventure of the Illustrious Client' after Holmes is involved in a scuffle. Holmes' attending physician, Sir Leslie Oakshott, tells Watson when he arrives: "Two lacerated scalp wounds and some considerable bruises. Several stitches have been necessary. Morphine has been injected and quiet is essential, but an interview of a few minutes would not be absolutely forbidden." These are the only two references in the stories.

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Q: Did Sherlock Holmes take Morphine
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