Chargaff's rules state that DNA from any cell of all organisms should have a 1:1 ratio of pyrimidine and purine bases and, more specifically, that the amount of guanine is equal to cytosine and the amount of adenine is equal to thymine.
Chargaff's rule states for every Adenine there's a thymine and for every cytosine there' a guanine
Erwin Chargaff
Watson and Crick came up with the base-pairing rule for nucleic acids using Chargaff's rule that in DNA the percentages of adenine and thymine are equal, and the percentages of guanine and cytosine are equal. Refer to the related link below.
Base Pairing Rules
The nucleotide to be added is determined by the nucleotide on the DNA stand. They always come in pairs. G matches with C and A with T.
- Bond angles - Bond lengths - The location of hydrogen atoms - Chargaff's pairs (although he didn't recognize them at the time)
Ernest Chargaff (Austrian) and Waclaw Szybalski (Polish).
James Watson and Francis Crick are credited with the base pairing rules and DNA structure in general. Erwin Chargaff is credited with the rules of base pairs in that the number of pyrimidines is equal to the number of purines.
Base pairing rules and complementary base rules are related because of DNA. If one can find the base pairing on a strand of DNA, usually the complementary base is easily found.
Chargaff's rule means that there should be the same number of purine and pyrimidine bases in DNA. The base pairing rules means that A always pairs with T, and G always pairs with C ie. a purine always pairs with a pyrimidine, so there must be the same number of both proving Chargaff's rule.
Erwin Chargaff
in the 1950's
Erwin Chargaff
Chargaff's rule means that there should be the same number of purine and pyrimidine bases in DNA. The base pairing rules means that A always pairs with T, and G always pairs with C ie. a purine always pairs with a pyrimidine, so there must be the same number of both proving Chargaff's rule.
Watson and Crick came up with the base-pairing rule for nucleic acids using Chargaff's rule that in DNA the percentages of adenine and thymine are equal, and the percentages of guanine and cytosine are equal. Refer to the related link below.
Base Pairing Rules
James Watson and Francis Crick are credited with the base pairing rules and DNA structure in general. Erwin Chargaff is credited with the rules of base pairs in that the number of pyrimidines is equal to the number of purines.
Chargaff