Anne Costello, Lou Costello's wife, died in 1959 due to a rheumatic heart condition. Lou was devastated by her passing and it deeply affected him for the rest of his life.
Anne of Cleves died of natural causes, she out lived Henry although wasn't his last wife she was his fourth.
If you mean Anne as in Henry viii 2nd wife then she was beheaded (according to Henry for being a witch)
If she was not beheaded, she was his one wife who died of natural causes.
=What year did Anne Bonny Die?==What year did Anne Bonny Die?=
Lou Sullivan died in 1991.
Lou Guisto died in 1989.
Lou Bender died in 2009.
Lou Stein died in 2002.
Lou Heim died in 1954.
Lou Groen died in 2011.
Lou Kahn died in 2002.
Lou Heard died in 1987.