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The closest portion of Iowa to Colorado is near Sioux City. This is about 320 miles (515 km) from the NE corner of Colorado near Julesberg. There are no direct interstate highway routes, so the driving distance is closer from southern Iowa.

Council Bluffs, in extreme SW Iowa, is adjacent to Omaha, Nebraska. The driving distance from Omaha to the Colorado border (along I-80 / I-76 west) is about 357 miles (575 km) and to Denver is 538 miles (866 km).

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Q: How many miles is it from Iowa to Colorado?
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