Meningitis, by definition, is an inflammatory process of the meninges, which constitute the blood brain barrier (BBB). Inflammation makes the blood brain barrier more permeable to chemicals, such as antibiotics. Under normal circumstances, penicillin does not cross the BBB very well, but when inflamed, it can cross more readily.
Antibiotics that crosses BBB-
1 Cephalosporins:eg. Ceftriaxone, Cefotaxime, ceftazidime, cefepime
2) Penicillins: Ampicillin
3 Antifungals: Amp B with flucytosine, Fluconazole
4 Vancomycin
5 Anti-tuberculous drugs. eg. INH
Antidepressants, alcohol, cocaine
some of the drugs can cross blood-brain barrier, so it can affect neurons too.
Drugs which are administered percutaneously, sublingually, or have to cross the blood brain barrier have to be lipophilic.
The blood-brain-barrier.
The blood-brain barrier is an actual filter. Most molecules are too big to squeeze through it! This protects the delicate brain cells from a lot of toxins and poisons. It also keeps some chemicals inside the brain, where they can act to the most good.
Spleen
The blood brain barrier is effective again harmful chemicals in the blood and bacteria infections from reaching the brain. Many of the drugs on the street breach this barrier. K12 or bath salts is a very good example of the damage breaching this barrier can cause.
The Blood-Brain Barrier (BBB). This is actually a good website describing it : http://faculty.washington.edu/chudler/bbb.html
Yes, the brain has anatomical barriers that limit the entry of drugs. The blood-brain barrier (BBB) is a highly selective barrier formed by specialized endothelial cells that line the blood vessels in the brain. It prevents the passage of certain substances, including many drugs, from entering the brain tissue. The liver also has its own protective barriers, such as the hepatocyte membrane, which regulates the absorption and distribution of drugs.
The choroid plexus is in contact with the cells lining the ventricles, which helps in the formation of cerebrospinal fluid. The capillaries of the choroid plexus differ significantly from those found elsewhere in the body. As a result, drugs carried in the bloodstream may not effectively penetrate brain tissue. This phenomenon is referred to as the blood-brain barrier. In short, the choroid plexus helps create the barrier, as it is through it's capillaries that the barrier is formed.
I would guess IV, but inhalation of gaseous form would be close. Some drugs do not pass the blood brain barrier however.
Drugs impact the brain because it causes abnormal growth which eventually forms tiny, almost mircroscopic little short hairy gnomes inside the oppicatal canal of the coccxy. This gnomes are very irritable but can be removed surgically. The gnomes will play padie wac on your pariential lobe. If you listen close enough you can hear the awsome reggie beat their banging out. After awhile the beat will infect your nerves, which becomes a pounding. Take two of theze and youll be fine.