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The first thing you need to determine is why you want to get rid of the Spiders. The ones in the U.S. that can kill people are the black widows and the brown recluse spiders. Black widow bites can only kill children and infirm adults. Since antivenoms have been available, nobody has died from their bites. The brown recluse spiders can produce necrotic bites, and sometimes more serious symptoms, symptoms that can produce death, can result. Black widow spiders do not like to live in human habitations, so if you spot one the easiest solution would be to let it drop into a bottle, cap the bottle, take it outside, and release it at some distance from human habitation.

If you kill all spiders in your house, then there is a chance that many brown recluses spiders would get in, and there would be no other spiders around to catch and eat them.

If you are intent on killing, then the next problem would be what to use to kill them. A flyswatter would do for individual black widow or brown recluse spiders. If you don't like that solution you could try diatomaceous earth. That is not a drug like DDT. It is made up of large numbers of diatoms, or at least the shells of dead diatoms. Contact with them can pierce the bodies of insects and spiders.

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Q: What is a pet safe alternative to pesticides to get rid of spiders?
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