Endothelial dysfunction is a process in which the endothelium secretes substances that promote atherosclerotic plaque build-up rather than the protective substances that prevent this build-up. It is the earliest detectable stage of cardiovascular disease. The good news is that this condition is treateble and even reversible.
Cardiovascular disease risk factors can cause endothelial dysfunction: smoking, high blood pressure, Diabetes, high cholesterol levels, obesity and others. Endothelial dysfunction has been dubbed by investigators from the Mayo Clinic as "the ultimate risk of the risk factors"
Nitric-Oxide, as the name implies, is a molecule made of a single Nitrogen atom coupled with a single Oxygen atom. The discovery of its role in regulating the cardiovascular system in 1980 was awarded the Nobel Proze for medicine in 1998. Nitroc-Oxide, or NO, is considered the most important of the protective molecules the healthy endothlium secretes.
In general, endothelial dysfunction can be treated. Treatments include life style modifications, certain medications such as Statins or vasodilators (of the ACE-Inhibitor or ARB families) which can improve or even reverse endothelial dysfunction. There are several new lines of drugs investigated by Pharma companies to treat endothelial dysfunction and its underlying causes
Endothelial dysfunction is associated with most cardiovascular diseases, especially coronary artery disease, which can lead to a heart attack. Endothelial dysfunction is considered to be an early marker of coronary artery disease as it usually precedes it decades before any signs or symptoms appear. In fact, many investigators in the cardiovascular field view endothelial dysfunction as the disease whose clinical manifestation is cardiovascular disease.
Thrombosis, atherosclerosis, and hypertensive vascular lesions.
Shauna M. Dauphinee has written: 'Endothelial dysfunction and inflammation' -- subject(s): Diseases, Physiopathology, Vascular endothelium, Pathophysiology, Inflammation, Pathology, Endothelial Cells, Vascular Endothelium, Cardiovascular system
It is unknown how autism is linked to endothelial dysfunction but there is evidence that something is going on. A variation of the MET gene was more common in children the the GI form of autism. Angela Biggs Pediatrics DOI: 10.1524 peds.2008-0819 http://pediatrics.aappublications.org/cgi/content/abstract/123/3/1018?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=Distinct+Genetic+Risk+Based+on+Association+of+MET+in+Families+With+Co-occurring+Autism+and+Gastrointestinal+&searchid=1&FIRSTINDEX=0&volume=123&issue=3&resourcetype=HWCIT
ENDOTHELIAL
Yes, endothelial cells divide. It is important that these cells divide to replace old/dead cells and to create new blood vessels.
Endothelial cells also known as epithernal tissue.
Endothelial cells form the inner lining of a blood vessel and provides an anticoagulant barrier between the vessel wall and blood. Endothelial cells also generate an antithrombotic surface that facilitates transit of plasma and cellular constituents throughout the vasculature. As a selective permeability barrier, the endothelial cell is a unique multifunctional cell with critical basal and inducible metabolic and synthetic functions. The endothelial cell reacts with physical and chemical stimuli within the circulation and regulates hemostasis, vasomotor tone, and immune and inflammatory responses. In addition, the endothelial cell is pivotal in angiogenesis and vasculogenesis.
Dysfunction is a noun
Squamous epithelial lining of alveolus Endothelial cells lining an adjuacent capillary Fused basal laminae between alveolar and endothelial cells
Endothelial and epethelilal cells are the two different cell types which sandwich together the tissue. On the blood side is the endothelial cells (endo, meaning inside), and on the outer side are the epethelial cells. For example the epethelial cell layer are the cells that coat the intetestine wall, and thus absorb nutrients and the the endothelial cells are the cells that face the blood,and release those nutrients into the blood.