The Plasma Concentration is how much of a drug is in your blood. If injected IV, it will spike quickly. Otherwise there will be an absorption curve depending on the administration method. It will also have an exponential decay curve that generally follows half lives. The decay curves can, of course, be altered by things like kidney and liver function (where most drugs are either excreted or metabolized). The other to note is that some drugs are fat soluble and others are water soluble. Water soluble drugs are frequently excreted quickly through the kidneys. Fat soluble drugs can get stuck in your FAT and can stay in the body for an extended period. One additional thing about plasma concentration. The goal may be to keep the plasma concentration between a low "active" level and a high "toxic" level, with, of course, certain safeguards in place. Not all of the drug will be excreted before the second dose... and drugs can build up in the body over time. Sometimes a "loading dose" is good, for example starting with 3 aspirin for the first dose and 2 after that.
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Plasma half life is the most important factor determining the dosage frequency. it also decides the time taken for the drug to reach steady state plasma concentration, which takes about 4-5 half lives to achieve. we can calculate how long the drug is going to stay in the body by knowing its half life as it is the time taken for the drug concentration to halve.
in pharmacokinetics, we can use volume distribution (Vd) of a drug to calculate the dose that needs to be prescribed. volume distribution is the theoretical volume the drug will have to occupy (if it were uniformly distributed), to provide a concentration as it currently is in blood plasma. Vd = (amount of drug in blood) / (drug plasma concentration) children are physically smaller than adults, hence they will have a smaller volume distribution and hence only need to be prescribed a smaller dosage of the drug. h
300 mOsm
Plasma concentration is may occur in mass energy equatiion of albert einstein. E=mc2 All electric plasma can become clouds.
The normal concentration of sodium in the blood plasma is 136-145 mM
Most compounds are given as their concentration in blood plasma as well as with the conditions of collection. It is a form of standardization used in order to compare results across laboratories and over time. As blood volume and percent hematocrit (a measure of red blood cells) are fairly constant relative to body mass using the concentration in plasma ensures consistency in measurement. Another factor is that red blood cells are not equilibrated with the concentration of all compounds outside the cell equally. Transportation of compounds across the cell membrane is regulated.
300 mOsm
it shows in urine.
It is a way of representing the concentration of the virus particles in blood plasma
Hemoconcentration occurs when there is an increase in the concentration of blood cells as the result of the loss of plasma from the bloodstream. A decrease in volume of plasma and an increase in red blood circulating.