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The Plasma Concentration is how much of a drug is in your blood. If injected IV, it will spike quickly. Otherwise there will be an absorption curve depending on the administration method. It will also have an exponential decay curve that generally follows half lives. The decay curves can, of course, be altered by things like kidney and liver function (where most drugs are either excreted or metabolized). The other to note is that some drugs are fat soluble and others are water soluble. Water soluble drugs are frequently excreted quickly through the kidneys. Fat soluble drugs can get stuck in your FAT and can stay in the body for an extended period. One additional thing about plasma concentration. The goal may be to keep the plasma concentration between a low "active" level and a high "toxic" level, with, of course, certain safeguards in place. Not all of the drug will be excreted before the second dose... and drugs can build up in the body over time. Sometimes a "loading dose" is good, for example starting with 3 aspirin for the first dose and 2 after that.
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What is Significance of plasma drug concentration measurement?
klir
What is the significance of plasma drug concentration measurement?
klir
Why use plasma concentration rather than blood concentration in monitoring drug concentration in the body?
Most compounds are given as their concentration in blood plasma as well as with the conditions of collection. It is a form of standardization used in order to compare results across laboratories and over time. As blood volume and percent hematocrit (a measure of red blood cells) are fairly constant relative to body mass using the concentration in plasma ensures consistency in measurement. Another factor is that red blood cells are not equilibrated with the concentration of all compounds outside the cell equally. Transportation of compounds across the cell membrane is regulated.
How do you calculate total systemic clearance and renal clearance?
Total systemic clearance (Cl_total) can be calculated by dividing the dose of a drug administered by the area under the plasma concentration-time curve (AUC) for that drug: Cl_total = Dose / AUC. Renal clearance (Cl_renal) is determined by measuring the rate of drug excretion in urine and the plasma concentration of the drug: Cl_renal = (Urine concentration × Urine flow rate) / Plasma concentration. Both clearances provide insight into how effectively a drug is eliminated from the body, with total systemic clearance reflecting all elimination pathways and renal clearance focusing specifically on kidney function.
Clinical significance of determination plasma half life of drug?
Plasma half life is the most important factor determining the dosage frequency. it also decides the time taken for the drug to reach steady state plasma concentration, which takes about 4-5 half lives to achieve. we can calculate how long the drug is going to stay in the body by knowing its half life as it is the time taken for the drug concentration to halve.
What is the derivation of clearance?
Clearance is derived from the relationship between the rate of drug elimination from the body and its concentration in the plasma. Mathematically, it is defined as the volume of plasma from which a substance is completely removed per unit time, typically expressed in units like mL/min. The formula for clearance (Cl) is Cl = (Rate of elimination) / (Plasma concentration), where the rate of elimination is often measured in mg/min and plasma concentration in mg/mL. This concept is crucial in pharmacokinetics for understanding drug dosing and the duration of drug action in the body.
Why do children need smaller doses if medicines than adults need?
in pharmacokinetics, we can use volume distribution (Vd) of a drug to calculate the dose that needs to be prescribed. volume distribution is the theoretical volume the drug will have to occupy (if it were uniformly distributed), to provide a concentration as it currently is in blood plasma. Vd = (amount of drug in blood) / (drug plasma concentration) children are physically smaller than adults, hence they will have a smaller volume distribution and hence only need to be prescribed a smaller dosage of the drug. h
What refers to the amount of space a drug occupies?
The amount of space anything occupies is normally called its "volume".
What is the concentration of plasma?
300 mOsm
What is definition of plasma electrolytic concentration?
Plasma concentration is may occur in mass energy equatiion of albert einstein. E=mc2 All electric plasma can become clouds.
What affects the concentration blood plasma?
The concentration of blood plasma is influenced by several factors, including hydration levels, protein intake, and the body's metabolic state. Dehydration can lead to increased plasma concentration due to a reduction in the volume of plasma, while overhydration can dilute it. Additionally, liver function and the production of plasma proteins such as albumin play a crucial role in maintaining plasma concentration. Other factors, like hormonal regulation and certain medical conditions, can also impact plasma composition.
What is the osmotic concentration of plasma?
300 mOsm
