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What is slow binding kinetics?

Updated: 4/27/2022
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13y ago

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Slow binding kinetics is when kon is very slow in the relationship Kd =kon/koff.

For slow binding inhibition, it is when inhibitor binding to an enzyme results in a conformation change that doesn't allow the ES to form, eliminating the formation of product. This is demonstrated as:

E + I --> EI* -X-> P

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