What is the distance between Key West Florida and Tallahassee Florida?

Answer 1

640 miles taking this route:

1. Take U.S. 1 NORTH, from Key West, up to Florida's TURNPIKE (toll) - NORTH to ORLANDO, @ Homestead on the mainland.
2. Take the TURNPIKE (toll) - NORTH, thru Orlando, to I-75 NORTH, @ END - TURNPIKE, north of Orlando. (NOT off EXIT 39 towards Naples)
3. Take I-75 NORTH to I-10 WEST to TALLAHASSEE off EXIT 435 in Lake City.
4. Take I-10 WEST to Tallahassee.