It sounds like Catherine Keener (40 Year Old Virgin).
Catherine Keener.
Catherine Keener
Lecia Macryn is the voice on the Lazy Boy commercials.
Leslie Mann
Donna bullock
K
Elizabeth Bogush
Jennifer leigh
Lisa Cooley his wife
Deb D'Agostino is the female in the Fall 2012 commercials with the girl riding a motorcycle around the country. Deb D'Agostino is a model from NY.
Sounds like it's The Boss from MGS3
Sounds like Aisha Tyler to me.