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because the older types of anti psychotic medication had horrible side effects, such as joint and muscle pain. also many mentally ill patients feel like the medication numbs the good parts of themselves, for john nash I imagene it made concentrating on complicated maths equations difficult and it stopped his delusions which he may have still believed were real. I guess you'd need to ask him for his own reasons but thats my experienced opinion.

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Q: Why did John stop taking the medications in the beautiful mind?
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