No, LSD binds to other receptor sites besides those for serotonin, including dopamine and adrenergic receptors. Compared to compounds such as psilocybin, it is less selective for the 5-HT2A receptor.

LSD mainly affects the Cerebral Cortex. LSD is a serotonin receptor agonist and much of its hallucinogenic effects are thought to result from binding to the 5-HT2A serotonin receptor in particular. LSD also affects all subtypes of dopamine receptor and all subtypes of adrenoreceptor.

Depending on the hallucinogen, it may be either an agonist or an antagonist at certain receptors. Classic psychedelics such as LSD and psilocybin are 5-HT2A receptor agonists, whereas dissociatives (PCP, DXM, ketamine, etc.) are NMDA receptor antagonists. Deliriants, such as atropine and scopolamine, are muscarinic antagonists.

The active compounds in magic mushrooms (and their metabolites, as psilocybin is metabolized into psilocin, which is also present in the mushrooms) bind to a specific serotonin receptor in the brain, the 5-HT2A receptor. Activation of this receptor leads to the psychedelic effects through poorly understood mechanisms. Contrary to fairly widespread belief, these compounds have not been shown to be neurotoxic or cause damage to the brain.

The active compounds in magic mushrooms (and their metabolites, as psilocybin is metabolized into psilocin, which is also present in the mushrooms) bind to a specific serotonin receptor in the brain, the 5-HT2A receptor. Activation of this receptor leads to the psychedelic effects through poorly understood mechanisms. Contrary to fairly widespread belief, these compounds have not been shown to be neurotoxic or cause damage to the brain.