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When a chronic disease becomes exacerbated it means it has gotten worse. This may warrant the medical staff calling in the family.
It goes.
exacerbated, exasperated.
exacerbate
ex·ac·er·bate (ĭg-zăs'ər-bāt')
tr.v., -bat·ed, -bat·ing, -bates.
To increase the severity, violence, or bitterness of; aggravate: a speech that exacerbated racial tensions; a heavy rainfall that exacerbated the flood problems.
The rainfall exacerbated the flood problem.