No, Fragile X is on the X chromosome. Females have 2 X chromosomes and Males have an X and a Y Chromosome. Therefore, both males and females can have Fragile X (they can have the full mutation or be carriers). Males are usually more severly affected because they have only one X Chromosome.

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A situation that is near to being imbalanced is fragile. A person who gets easily sick is fragile. A glass that is easily broken is fragile and the rain forest is about to become imbalanced so it is fragile.