Acatalasia
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Acatalasia
| Acatalasia | |
|---|---|
| Classification and external resources | |
 Basic structure of a peroxisome |
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| ICD-10 | E80.3 |
| ICD-9 | 277.89 |
| OMIM | 115500 |
| DiseasesDB | 30598 |
| MeSH | D020642 |
Acatalasia (also called acatalasemia, or Takahara's disease[1]:809) is an autosomal recessive peroxisomal disorder caused by a complete lack of catalase.
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Contents
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Presentation
The disorder is relatively benign, although it causes an increased incidence of periodontal infections, and can under rare circumstances lead to gangrene.[2]
History
In 1948, Dr.Shigeo Takahara (1908–1994), a Japanese otolaryngologist first reported this new disease.[3] He had examined a patient with an oral ulcer. He had spread hydrogen peroxide on the diseased part, but oxygen was not generated due to the lack of catalase.
See also
References
- ^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
- ^ Takahara, Shigeo; Hamilton, H. B., Neel, J. V., Kobara, T. Y., Ogura, Y., Nishimura, E. T. (1960). "Hypocatalasemia: a new genetic carrier state". Journal of Clinical Investigation 39 (4). doi:10.1172/JCI104075. http://www.jci.org/articles/view/104075.
- ^ Takahara, S.; Miyamoto, H. Three cases of progressive oral gangrene due to lack of catalase in the blood. Nippon Jibi-Inkoka Gakkai Kaiho 51: 163 only, 1948.
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