Acipimox
Oxford A-Z of Medicinal Drugs:
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acipimox
A lipid-lowering drug that is a nicotinic acid derivative. It lowers both triglycerides and cholesterol and is therefore used in the treatment of a variety of hyperlipidaemias. It acts by inhibiting the breakdown of fats in fatty tissue, thereby typically causing a 20% fall in plasma low-density lipoproteins-cholesterol (see lipoproteins). It is available as capsules on prescription only.
Side effects:
vasodilatation, flushing, itching, and rashes may occur. Occasional side effects are heartburn, pain in the stomach region, nausea, headache, and diarrhoea.
Precautions:
acipimox should not be taken by people with severely impaired kidney function or peptic ulcer or by women who are pregnant or breastfeeding because of a lack of data on its safety.
Proprietary preparation:
Olbetam.
| acid-peptic diseases, aciclovir, acetylcysteine | |
| acitretin, acne, acrivastine |
Wikipedia on Answers.com:
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Acipimox
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| Systematic (IUPAC) name | |
| 5-carboxy-2-methyl-1-oxidopyrazin-1-ium | |
| Clinical data | |
| AHFS/Drugs.com | International Drug Names |
| Pregnancy cat. | ? |
| Legal status | ? |
| Routes | Oral |
| Identifiers | |
| CAS number | 51037-30-0  |
| ATC code | C10AD06 |
| PubChem | CID 5310993 |
| ChemSpider | 4470534 |
| UNII | K9AY9IR2SD |
| KEGG | D07190 |
| ChEMBL | CHEMBL345714 |
| Chemical data | |
| Formula | C6H6N2O3 |
| Mol. mass | 154.124 g/mol |
| SMILES | eMolecules & PubChem |
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Acipimox is a niacin derivative used as a hypolipidemic agent. It is used in low doses and may have less marked adverse effects, although it is unclear whether the recommended dose is as effective as are standard doses of nicotinic acid. Acipimox inhibits the production of triglycerides by the liver and the secretion of VLDL, which leads indirectly to a modest reduction in LDL and increase in HDL. Long-term administration is associated with reduced mortality, but unwanted effects limit its clinical use. Adverse effects include flushing (associated with Prostaglandin D2), palpitations, and GI disturbances. Flushing can be reduced by taking aspirin 20-30 min before taking Acipimox. High doses can cause disorders of liver function, impair glucose tolerance and precipitate gout.
Brands available : Acipicap from Zydus Cadila
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Oxford A-Z of Medicinal Drugs
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