Acrivastine
Drug Info:
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Acrivastine; Pseudoephedrine
Brand names: Semprex-D®
Chemical formula:
Acrivastine, Pseudoephedrine Hydrochloride Oral capsule
What is this medicine?
ACRIVASTINE; PSEUDOEPHEDRINE (AK ri vas teen; soo doe e FED rin) is a combination of an antihistamine and a decongestant. It is used to treat the symptoms of seasonal allergies. This medicine will not treat an infection.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
• diabetes
• glaucoma
• high blood pressure or heart disease
• if you have taken an MAOI like Carbex, Eldepryl, Marplan, Nardil, or Parnate in last 14 days
• kidney disease
• pain or difficulty passing urine
• ulcers or other stomach problems
• an unusual or allergic reaction to acrivastine, triprolidine, pseudoephedrine, phenylpropanolamine, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding
How should I use this medicine?
Take this medicine by mouth with a full glass of water. Follow the directions on the prescription label. Take your medicine at regular intervals. Do not take your medicine more often than directed.
Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 12 years of age for selected conditions, precautions do apply.
Patients over 60 years old may have a stronger reaction and need a smaller dose.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.What may interact with this medicine?
Do not take this medicine with any of the following medications:
• amphetamine or other stimulant drugs
• dihydroergotamine, ergotamine
• MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
This medicine may also interact with the following medications:
• alcohol
• barbiturates, like phenobarbital
• medicines for blood pressure
• medicines for depression, anxiety, or psychotic disturbances
• medicines for sleep
• muscle relaxers
• narcotic pain medicines
• other medicines for cold, cough or allergy
• some heart medicines like metoprolol
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
What should I watch for while using this medicine?
Visit your doctor or health care professional for regular check ups. Tell your doctor if your symptoms do not improve or if they get worse.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.
Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
• allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
• confused, agitated, nervous
• fast, irregular heartbeat
• tremor
• trouble breathing
• trouble passing urine
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
• cough
• dizzy
• drowsy, tired
• dry mouth, nose, throat
• headache
• stomach upset, nausea
• trouble sleeping
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Where should I keep my medicine?
Keep out of the reach of children.
Store at room temperature between 15 and 25 degrees C (59 and 77 degrees F). Keep away from heat and light. Throw away any unused medicine after the expiration date.
Last updated: 7/1/2002
Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.
Oxford A-Z of Medicinal Drugs:
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acrivastine
One of the newer (non-sedating) antihistamines, used to relieve the symptoms of such allergic conditions as hay fever and urticaria. It is available as capsules on prescription, and packs containing no more than 10 days' supply can be obtained from pharmacies without a prescription.
Side effects, precautions, and interactions with other drugs:
see antihistamines.
Proprietary preparations:
Benadryl Allergy Relief; Benadryl Plus Capsules (combined with pseudoephedrine hydrochloride).
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Wikipedia on Answers.com:
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Acrivastine
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|---|---|
| Systematic (IUPAC) name | |
| (E)-3-{6-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-yl- prop-1-enyl]pyridin-2-yl}prop-2-enoic acid |
|
| Clinical data | |
| AHFS/Drugs.com | International Drug Names |
| MedlinePlus | a682619 |
| Pregnancy cat. | B (US) |
| Legal status | ℞-only (US) |
| Routes | oral |
| Pharmacokinetic data | |
| Half-life | 1.5 hours |
| Excretion | Renal |
| Identifiers | |
| CAS number | 87848-99-5  |
| ATC code | R06AX18 |
| PubChem | CID 5284514 |
| ChemSpider | 4447574  |
| UNII | A20F9XAI7W |
| KEGG | D02760 |
| ChEMBL | CHEMBL1224 |
| Chemical data | |
| Formula | C22H24N2O2 |
| Mol. mass | 348.438 g/mol |
| SMILES | eMolecules & PubChem |
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 (what is this?) (verify) |
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Acrivastine(modification of triprolidine) (nonsedating anti histamines) is a medication used for the treatment of allergies and hay fever. It is a second-generation H1-receptor antagonist antihistamine and works by blocking Histamine H1 receptors.
It is sold under the brand name Benadryl Allergy Relief in the U.K. by McNeil Laboratories, not to be confused with Benadryl Once a Day, which is cetirizine and is also sold by McNeil in the U.K. It is available as an over-the-counter medication in the UK.
In the U.S., acrivastine is the active ingredient in the Semprex-D brand. Semprex-D is also acrivastine-based, but contains a decongestant, pseudoephedrine. Semprex-D is marketed in the U.S. by Actient Pharmaceuticals LLC.[1][2]
Comparisons with other popular antihistamines
Unlike cetirizine or loratadine, the standard dosage of which is one tablet every day, a single acrivastine tablet may be taken up to three times a day.[3] This can make it substantially more expensive than cetirizine or loratadine. Additionally, acrivastine is taken as a capsule, whereas cetirizine and loratadine are usually sold as tablets.
References
- ^ [1] Actient Pharmaceuticals
- ^ SEMPREX-D - acrivastine and pseudoephedrine hydrochloride capsule U.S. National Library of Medicine, National Institutes of Health, May 2008
- ^ http://www.medicines.org.uk/EMC/pdfviewer.aspx?isAttachment=true&documentid=21852
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Oxford A-Z of Medicinal Drugs
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