n.

A hormone produced by the anterior lobe of the pituitary gland that stimulates the secretion of cortisone and other hormones by the adrenal cortex. Also called adrenocorticotropin, corticotropin.

[A(DRENO)C(ORTICO)T(ROPIC) H(ORMONE).]

See adrenocorticotrophic hormone.

n
adrenocorticotropic hormone

Hormone produced by basophilic cells of the anterior lobe of the pituitary gland that exerts a reciprocal regulating influence on the production of corticosteroids by the adrenal cortex.

Brand names: Acthar®, H.P. Acthar®

Español:
• Gel para inyección o inyección de corticotropina, ACTH

Corticotropin, ACTH injection or injection gel

What is corticotropin?

CORTICOTROPIN (Acthar®) is a hormone that occurs naturally in the body. Corticotropin causes the adrenal gland to release cortisol. Corticotropin most often is used to test the function of the adrenal gland. Corticotropin can also reduce inflammation in various other conditions, but has largely been replaced by other corticosteroids. Generic corticotropin injections are available.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
• Cushing's syndrome
• heart or circulation problems, or blood clots
• high blood pressure
• high blood sodium level
• infection, such as herpes
• liver disease
• low blood potassium level
• osteoporosis
• peptic ulcer
• recent surgery
• scleroderma
• under-active thyroid
• an unusual or allergic reaction to corticotropin, corticosteroids, pork proteins, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I use this medicine?

For diagnostic purposes corticotropin is infused into a vein. For other treatments corticotropin is for injection into a muscle or under the skin. It is given by a health-care professional in a hospital or clinic setting.

What if I miss a dose?

This does not apply.

What drug(s) may interact with corticotropin?

• acetazolamide
• amphotericin B
• antiinflammatory drugs (NSAIDs, such as ibuprofen)
• aspirin and aspirin-like medicines
• barbiturate medicines for inducing sleep or treating seizures
• bosentan
• calcium supplements
• certain heart medicines
• female hormones, including contraceptives or birth control pills
• growth hormone
• medicines for diabetes
• phenytoin
• potassium salts
• rifampin
• water pills

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What should I watch for while taking corticotropin?

Visit your prescriber or health care professional for regular checks on your progress. If you are receiving corticotropin over a prolonged period, carry an identification card with your name, address, the type and dose of corticotropin, and your prescriber's name and address.

If you are receiving corticotropin regularly, avoid contact with people who have an infection. You will have an increased risk of infection while receiving corticotropin. Do not receive any vaccinations as you may get a strong reaction. Avoid people who have recently taken oral polio vaccine. Tell your prescriber or health care professional if you are exposed to anyone with measles or chickenpox, or if you develop sores or blisters that do not heal properly.

If you are going to have surgery, tell your prescriber or health care professional that you have received corticotropin within the last twelve months.

Corticotropin can interfere with certain lab tests and can cause false skin test results.

What side effects may I notice from receiving corticotropin?

Side effects that you should report to your prescriber or health care professional as soon as possible:
• bloody or black, tarry stools
• confusion, excitement, restlessness, a false sense of well-being
• decreased or blurred vision
• fever, sore throat, sneezing, cough, or other signs of infection, wounds that will not heal
• frequent passing of urine
• hallucinations (seeing and hearing things that are not really there)
• increased thirst
• irregular heartbeat
• mental depression, mood swings, mistaken feelings of self-importance or of being mistreated
• menstrual problems
• muscle cramps or weakness
• nausea, vomiting
• pain in hips, back, ribs, arms, shoulders, or legs
• pain, redness, swelling, signs of allergy, or scarring at the injection site
• rounding out of face
• skin problems, acne, thin and shiny skin
• stomach pain
• swelling of feet or lower legs
• unusual bruising, pinpoint red spots on the skin
• unusual tiredness or weakness
• weight gain

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
• increased appetite
• nervousness, restlessness, or difficulty sleeping
• upset stomach
• unusual increased growth of hair on the face or body

Where can I keep my medicine?

Keep out of the reach of children.

After mixing store in a refrigerator between 2 and 8 degrees C (36 and 46 degrees F) or use within 24 hours if kept at room temperature. Throw away any unused injection solution.

Last updated: 7/1/2002

Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.

For more information on ACTH, visit Britannica.com.

Adrenocorticotropic hormone; produced by the anterior lobe of the pituitary gland that stimulates the cortex of the adrenal gland to secrete its hormones, including corticosterone. If production of ACTH falls below normal, the adrenal cortex decreases in size, and production of the cortical hormones declines. Called also adrenocorticotropin and corticotropin.
Its principal use is as a diagnostic agent: e.g. in the differentiation of primary adrenocortical neoplasia and adrenocortical hyperplasia.

• ACTH assay — determination of plasma levels of ACTH may be used to identify pituitary-dependent hypo- or hyperadrenocorticism.
• ACTH cells — see chromophobe.
• ACTH gel — a commercially available form of ACTH in gelatin with prolonged action.
• ACTH response test, ACTH stimulation test — measures the secretory capacity of the adrenal cortex in response to a supraphysiological dose of exogenous ACTH. This test is commonly used in the diagnosis of hyperadrenocorticism in dogs. An increased response is consistent with adrenocortical hyperplasia.
• ACTH-secreting adenoma — see corticotroph adenoma.